Cysteinyl-Leukotrienes in Cerebrovascular Disease
نویسندگان
چکیده
منابع مشابه
Cysteinyl-leukotrienes in cerebrovascular disease: angels and demons?
Although the initial interest in the field of leukotriene (LT) research was focused on their potent bronchoconstrictive effects, subsequent studies have suggested LTs as key mediators in several inflammatory diseases. Genetic variations within the enzymes transforming arachidonic acid into LTs (Figure) have for example been associated with atherosclerosis and an increased risk of cardiovascular...
متن کاملIncreased generation of cysteinyl leukotrienes in Kawasaki disease.
Endogenous cysteinyl leukotriene synthesis was assessed in 10 patients with Kawasaki disease and 10 healthy controls by measuring excretion of leukotriene E4 (LTE4) in urine. LTE4 was increased more than fivefold in patients with Kawasaki disease compared with controls (median (range) 55.3 (31.8-120.6) v 10.2 (7.1-14.9) nmol/mol creatinine); this suggests that cysteinyl leukotrienes are involve...
متن کاملCysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have ...
متن کاملCysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice.
BACKGROUND Sepsis impairs hypoxic pulmonary vasoconstriction (HPV) in patients and animal models, contributing to systemic hypoxemia. Concentrations of cysteinyl leukotrienes are increased in the bronchoalveolar lavage fluid of patients with sepsis, but the contribution of cysteinyl leukotrienes to the impairment of HPV is unknown. METHODS Wild-type mice, mice deficient in leukotriene C(4) sy...
متن کاملAdipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma
Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims. Our hypothesis is that increased leptin and decreased adiponectin levels in obese subjects play a direct role in regulating inflammation in asthmatics. We wanted to examine the hypothesis that cysteinyl leukotrienes (cys-LT), inflammator...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2008
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.108.164459